Adrenomedullin 2 activates extracellular-signal-regulated kinase in endothelial cells via a protein kinase C α-independent pathway [version 1; referees: 2 approved with reservations]

Adrenomedullin 2 plays diverse physiological roles such as regulating cardiovascular functions and blood pressure. It was reported that adrenomedullin 2 can activate protein kinase C in murine ventricular myocytes to augment cardiomyocyte contractile function. Using a protein kinase Cα knockout mouse model, we show here that adrenomedullin 2 activates extracellular-signal-regulated kinase in a protein kinase Cα-independent mechanism in endothelial cells. Michael Simons ( ) Corresponding author: [email protected] Guo X, Ju R, Cha C and Simons M. How to cite this article: Adrenomedullin 2 activates extracellular-signal-regulated kinase in endothelial cells via a protein kinase C α-independent pathway [version 1; referees: 2 approved with reservations] F1000Research 2016, :26 (doi: ) 5 10.12688/f1000research.2420.1 © 2016 Guo X . This is an open access article distributed under the terms of the , which Copyright: et al Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the (CC0 1.0 Public domain dedication). Creative Commons Zero "No rights reserved" data waiver This work is supported by OHSE fund (Department of Surgery, Yale School of Medicine) funding to XG. Grant information: Competing interests: There is no disclosure of competing interests. 06 Jan 2016, :26 (doi: ) First published: 5 10.12688/f1000research.2420.1 1 2 1